Sunday, Nov 17
REGISTRATION
12:20
Light Lunch and Registration
SESSION 1: IMMUNE REPERTOIRES 1
CHAIR: MARK SHLOMCHIK
14:00
Speakers:
Gur Yaari - Opening remarks
Danny Douek- Host Genetic Factors that Affect HIV Acquisition and Vaccine Efficacy
Nir Friedman - Stereotypical organization of young T cell receptor repertoires that disrupts with age
Thomas Hofer - TBD
COFFEE BREAK
15:40
coffee break
SESSION 2: IMMUNE REPERTOIRES 2
CHAIR: DANNY DOUEK
16:05
Speakers:
Paula Oliver- Cullin complexes that regulate distinct T cell functions
Tal Shay - The splicing programs of the mouse immune systems
Deborah Dunn Walters - Ig repertoire of Ebola survivors
COFFEE BREAK
17:20
coffee break
OPENING KEYNOTE
17:45
Yehudit Bergman - Epigenetic programming of immunoglobulin allelic choice
WELCOME RECEPTION
18:35
welcome reception
Monday, Nov 18
SESSION 3: COMPUTATIONAL METHODS FOR REPERTOIRE IMMUNOLOGY
CHAIR: RAMIT MEHR
9:00
Speakers:
Mikhail Shugay - Integrating immunoinformatic approaches and databases to predict antigen exposure imprint and immunogenicity of self and foreign antigens
Yuval Elhanati - What can we learn from statistical models on the diversity of the adaptive immune system
Lindsey Cowell - Statistical Classifiers for Identifying Phenotype-Associated Biophysicochemical Motifs in AIRR
Eilon Sherman - Resolving mechanisms of T cell activation at the single molecule level
COFFEE BREAK
10:40
coffee break
SESSION 4: MODELLING IMMUNITY
CHAIR: DEBORAH DUNN WALTERS
11:05
Speakers:
Becca Asquith -The “stemness” of immune memory
Johannes Textor - To what extent does the T cell receptor sequence determine the outcome of positive selection?
Ramit Mehr - Identifying a malignant B-cell Lymphoma clone in the peripheral blood using Immunoglobulin high-throughput sequencing and lineage tree analysis
LUNCH
12:20
lunch
OPTIONAL
14:00
Mikhail Shugay
COFFEE BREAK
16:05
coffee break
SESSION 5: CONTRIBUTED TALKS FROM ABSTRACTS 1
CHAIR: CHRISTIAN BUSSE
16:30
Speakers:
Chaim Schramm - Active Recombination and Transcription of Human VH Pseudogenes in Peripheral B Cells
Linnea Thörnqvist - Refined definition of stereotyped rearrangements associated with IgE responses against the timothy grass pollen allergen Phl p 2
Natanael Spisak - Models for somatic hypermutation
Kenneth Hoehn - Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccination
POSTER SESSION 1
18:35
poster session 1 & snacks
Tuesday, Nov 19
SESSION 6: EVOLOUTION OF IMMUNITY ACROSS MULTIPLE TEMPORAL SCALES
CHAIR: URI HERSHBERG
9:00
Speakers:
Bartlomiej Swiatczak - Genomic stress response and lymphocyte evolvability
Irun Cohen - Immune system networks – innate and antigen specific – prime immune system machine learning.
Yoram Louzoun - Prediction of specific TCR-peptide binding from large dictionaries of TCR-peptide pairs
Leila Perie - Family matters: the role of single cell families in hematopoiesis
COFFEE BREAK
10:40
coffee break
SESSION 7: IMMUNE RESPONSES
CHAIR: YORAM LOUZOUN
11:05
Speakers:
Sol Efroni - The T-cell repertoire as a biomarker for response to anti PD-1 immunotherapy
Ziv Shulman - TBD
David Klatzmann - How specific is specific in the T cell response? - Opus 2
LUNCH
12:20
lunch
OPTIONAL
14:00
Planning and intro for IMMREP20 meeting in Dresden
or
General discussion of combining other data types with AIRR-seq data Moderator: Felix Breden
COFFEE BREAK
16:05
coffee break
SESSION 8: CONTRIBUTED TALKS FROM ABSTRACTS 1
CHAIR: TOMER HERTZ
16:30
Speakers:
Julia Leman - Inhibitory receptor expression by Tregs in colorectal tumours
Miriam I. Rosenberg - Anti-tumor response in neuroblastoma associated with Opsoclonus Myoclonus Syndrome bears hallmarks of autoimmunity
Yariv Wine - Insight into mechanisms of immunogenicity following treatment with therapeutic monoclonal antibodies
Lisa Buchauer - Clonal tracking and mathematical modeling of CD8+ T cell activation reveals low intrinsic variability governed by narrow, non-Markovian distributions of activation and division times
POSTER SESSION 2
18:35
poster session 2 & snacks
Wednesday, Nov 20
SESSION 9: SINGLE CELL DYNAMICS
CHAIR: SOL EFRONI
9:00
Speakers:
Yanay Ofran - Using repertoires to design antibodies that bind specific epitopes and proteins that avoid specific antibodies
Tomer Hertz - TBD
Christian Busse - Known-sequence mutational scanning of B1.8-NP interaction
Michal Or-Guil - Advancing discovery of clinical knowledge by exploitation of functional antibody landscapes
COFFEE BREAK
10:40
coffee break
SESSION 10: SYSTEMS IMMUNOLOGY ASPECTS OF IMMUNE REPERTOIRES
CHAIR: DAVID KLATZMANN
11:05
Speakers:
Esti Yeger-Lotem - A computational view into the CD4 T cell landscape in aging
Shai Shen-Orr - Cellular variability in the immune system: Origins, dynamics and clinical implications
Encarnita Mariotti-Ferrandiz - T-Cell Receptor (TCR) signatures of disease and of T cell subsets revealed by robust high-throughput TCR sequencing
LUNCH
12:20
lunch
POSTER PRIZE ANNOUNCEMENT
15:40
Poster prize announcement
SESSION 11: IMMUNE REPERTOIRES 3
CHAIR: FELIX BREDEN
16:05
Speakers:
Kobi Maman - Intra-Vκ Cluster Recombination Shapes the Ig Kappa Locus Repertoire
Victor Greiff - A finite vocabulary of antibody-antigen interaction enables predictability of paratope-epitope binding
Uri Hershberg - Closing remarks - Some more thoughts on selection at different scales
COFFEE BREAK
17:20
coffee break
CLOSING KEYNOTE
17:45
Mark Shlomchik - Control of and Outcomes of Canonical and Non-Canonical B Cell Responses
NETWORKING EVENT
18:35
Networking event
Thursday, Nov 21
EXCURSION
9:00
excursion to Bahai Gardens and Acre